Nerve damage caused by diabetes. Osteoporosis. Taking evening primrose oil with fish oil and calcium seems to decrease bone loss and increase bone density in elderly people with osteoporosis.

Side Effects:
It might cause mild side effects including upset stomach, nausea, diarrhea, and headache in some people.

Precautions:
Taking evening primrose oil by mouth is possibly safe during pregnancy. Evening primrose is possibly safe when taken by mouth in doses up to 6 grams daily. It is also possibly safe when applied to the skin.Evening primrose might increase the chance of bruising and bleeding. Don’t use it if you have a bleeding disorder.